Pregabalin is an analgesic and an anticonvulsant medication that is used to treat conditions like neuropathic pain, generalized anxiety disorder, and epilepsy. It is sold under various brand names, such as Lyrica and Nervigesic, among others. However, just like other medicines, Pregabalin comes with a set of potential adverse events. One concern that frequently arises among people taking Pregabalin is weight gain.

In this blog, let’s explore the relationship between  Pregabalin and weight gain.

Does Lyrica Cause Weight Gain?

Putting on weight is one of the possible side effects associated with Pregabalin use. However, the majority of people prescribed Nervigesic won’t gain weight or will gain only a small amount. The reported incidence of weight gain while taking Pregabalin ranges from 2% to 14.8% of patients [1].

Why Does Pregabalin Cause Weight Gain?

Some of the possible factors behind gaining weight while taking Pregabalin are –

Higher dose of Pregabalin and prolonged duration of use: Weight gain due to Pregabalin use can be related to the duration and dose of taking it. A study included people taking Lyrica for neuropathic pain and found an average weight gain of 3.6 lbs during 12-18 month follow-up. The patients who took higher doses of the medication gained more weight (an average of 6.5 lbs) [2].

Misuse of alcohol or drugs: Abusing substances such as alcohol or narcotics can impact the metabolism of a person, often resulting in a person gaining or losing weight. There is also the possibility of drug interaction between Pregabalin and controlled substances or alcohol, which may result in fluid retention or weight gain.

Use of other medications:  A study published in 2002 concluded that people taking Lyrica for epilepsy gained around 4 kg over a six-month follow-up. However, these patients were also taking other epilepsy medications, and weight gain was correlated with high total medication use [3].

Pregabalin may also increase users’ appetite or make them sleepy, reducing their activity. Pregabalin is also linked with fluid retention, especially in the limbs, which can increase weight. In clinical trials, the incidence of peripheral edema was reported to be around 6% in the Pregabalin group compared with 2% in the placebo group [4].

Should You Be Worried About Weight Gain Due To Pregabalin?

For most individuals, the weight gain associated with Pregabalin is minor and not enough to increase their body mass index and risk for adverse health outcomes. For example, the weight gain caused by Pregabalin does not cause significant changes in blood pressure.

However, if you feel you’re putting on too much weight while taking Pregabalin, it is best to consult a medical provider.

How To Avoid Weight Gain On Pregabalin?

You can avoid weight gain on Pregabalin by taking the following steps discussed below.

• Consult a dietician who can help you get a healthy diet plan to satisfy your hunger pangs and control your weight.
• Eat a balanced, healthy diet. If you feel Pregabalin has increased your appetite, add protein (lean protein such as fish, skinless poultry, and dried beans) and add a small amount of healthy fats to your daily diet. These foods take time to digest and can make you feel fuller for longer.
• Try to add at least 30 minutes of exercise to your everyday routine to avoid weight gain due to Pregabalin use. If Nervigesic reduces body pain due to neuropathy or other conditions, you may find exercise gets easier.

If you want to get rid of body pain due to neuropathy, you can explore our Pregabalin category page to order Nervigesic, a popular brand version of Pregabalin.

Other Pregabalin Side Effects

Other side effects of Pregabalin are blurred vision, trouble concentrating, dizziness, dry mouth, swelling of your feet or hands, and sleepiness. In severe cases, this drug can cause allergic reactions, suicidal thoughts, and fluid retention.

Pregabalin Warnings

• The use of Pregabalin can cause severe allergic reactions. In such cases, stop taking Pregabalin and seek emergency medical help.
• If you’ve diabetes or heart problems, inform your doctor before taking the medication.
• Do not stop taking Pregabalin abruptly, even if you feel fine, because suddenly stopping may cause withdrawal symptoms.
• Avoid drinking alcoholic beverages as it may increase the risk of certain side effects of Lyrica.
• Pregnant and breastfeeding women should avoid the use of Pregabalin without consulting a health care provider first.

Conclusion

Pregabalin is a potent treatment option for many, but like any medicine, it comes with potential adverse effects, including weight gain. While not every individual will experience this, it’s something to be aware of. By following healthy lifestyle habits and talking with your doctor, you can manage weight gain caused by the medication.